Vanderbilt VICB Molecular Design and Synthesis Center (MDSC)

Overview of Services

The Chemical Synthesis Core was established within the Vanderbilt Institute of Chemical Biology to support the organic and medicinal chemistry needs of Vanderbilt investigators.

The primary focus of the core is to facilitate biology-oriented projects within the medical center and the university by assisting with the chemistry aspect of the project. The core works independently or in collaboration with the VICB High Throughput Screening Center on the synthesis of literature-cited compounds (including patented ones) as well as full scale lead optimization of a compound.

The Core supports the Vanderbilt community in all aspects of medicinal and organic synthesis. We provide quantities of known or unknown compounds with an emphasis on parallel synthesis of small libraries, HPLC purification, and scale-up of synthetic procedures. Services include:
• Custom synthesis of compounds
• Synthesis and design of small molecule probes
• Dye synthesis
• Prostaglandin synthesis
• Compound libraries
• Medicinal chemistry
• Large-scale synthesis (up to 100g)
• HPLC purification capabilities
• Analytical support (NMR, MS)

Leadership

Guttentag, Ben	Research Assistant, senior
Romaine,Ian M	Drug Discovery Scientist
Christov,Plamen P	Drug Discovery Scientist, senior
Sulikowski, Gary	Professor
Tian, Jianhua	Drug Discovery Scientist, senior

Location and hours of operation

Hours
Monday - Friday   8AM-4PM

Links and Resources

1. https://medschool.vanderbilt.edu/syncore/

Contacts

Name	Role	Phone	Email	Location
Plamen Christov	Director	615-322-6072	plamen.p.christov@vanderbilt.edu
Sydnee Elmore	Lab Manager		sydnee.elmore@vanderbilt.edu

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