Vanderbilt Center for Structural Biology Cryo Electron Microscopy Facility

Overview 

The goal of the Center for Structural Biology Cryo Electron Microscopy Facility is to make molecular EM accessible to all interested researchers at Vanderbilt. Molecular-EM is one of the fastest developing, cutting-edge structural techniques for exploring the organization of biological macromolecules. The unique strength of molecular EM is its versatility. Structures determined using molecular EM can span resolution ranges from very low- to atomic-levels (>30–1.8Å) and do not require crystalline samples for analysis. The CSB Cryo-EM Facility provides researchers with access to state-of-the-art equipment, training and expert technical support for high resolution data collection and structural analysis of biological specimens using single particle analysis and tomography. This support ranges from specimen preparation, data collection, image processing, computational image analysis, and structure determination.

Services Offered

• Transmission electron microscopy
• Cryo-transmission electron microscopy
• Negative staining with uranyl formate
• Sample vitrification
• Data processing and analysis
• Expert training and consulting on equipment operation, sample preparation, and data analysis

Leadership

Locations and hours of operation

Links and Resources

1. CSB Cryo-Electron Microscopy Facility

Contacts